It is necessary for normal endochondral ossification, the process by which the growing skeleton is formed. Mice lacking this gene often exhibit dwarfism and craniofacial abnormalities due to impaired chondrocyte proliferation.
In oncology, miR-140 is widely investigated as both a biomarker and a therapeutic target due to its heavy involvement in cell carcinogenesis. 140 РђРЅРѕРЅСЃ
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A clinical review published on PubMed demonstrates that miR-140 heavily dictates how sensitive cancer cells are to chemotherapy drugs like doxorubicin, cisplatin, and temozolomide. Up-regulating its expression can actively enhance the efficacy of these treatments.