: This binding creates physical pores or channels in the membrane. Small essential molecules and cellular organelles leak out of these pores, causing cell death. Common Examples : Amphotericin B, nystatin , and natamycin. 3. Echinocandins
: This class targets the fungal cell wall rather than the membrane. They inhibit the enzyme -(1,3)-D-glucan synthase. Effect : This blocks the synthesis of antifungal agent
: Azoles inhibit the cytochrome P450-dependent enzyme lanosterol : This binding creates physical pores or channels
: Blocking this enzyme leads to ergosterol depletion and the accumulation of toxic methylated sterols, ultimately altering membrane function and stopping growth. antifungal agent