This generation is widely regarded as the best used option due to its current-feeling tech (MBUX), modern platform, and improved safety ratings.
Diesel models from 2008–2016 with rear-mounted timing chains (OM651) can cost $4,000–$7,000 just for chain servicing because the engine must be removed for access. Inspection Checklist for 2026
The OM654 2.0 diesel engine (found in the E200d and E220d models) is highly recommended for its blend of reliability and fuel efficiency.
Avoiding certain model years is essential to prevent "financial and emotional burden" from high failure rates:
These years are frequently flagged for engine balance shaft issues (specifically the E350 V6) and susceptibility to rust/corrosion.
2022 Mercedes-Benz E-Class Depreciation Value | Kelley Blue Book
Based on recent reliability data and long-term ownership patterns, experts suggest focusing on these specific generations: