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Convert(int,sys.fn_sqlvarbasetostr(hashbytes('md5','1522521276'))) -

The T-SQL expression convert(int,sys.fn_sqlvarbasetostr(HashBytes('MD5','1522521276'))) returns the integer value . Breakdown of the Execution

: SQL Server takes the beginning of that hex string and attempts to fit it into a 4-byte integer. Because the first 4 bytes ( 0xE4F3F000 ) represent a value larger than the maximum positive signed integer (

: Generates a 128-bit MD5 hash of the string '1522521276'. The resulting binary value is 0xE4F3F000CC6A3F98F7A831A601E6E002 .

Krasnov V.S.

Pavlov First St. Petersburg State Medical University

Kolontareva Yu.M.

Novartis Pharma LLC

convert(int,sys.fn_sqlvarbasetostr(HashBytes('MD5','1522521276')))

Siponimod: a new view at the therapy of secondary progressive multiple sclerosis

Authors:

Krasnov V.S., Kolontareva Yu.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(7): 124‑129

DOI: 10.17116/jnevro2021121071124

Read: 10020 times

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convert(int,sys.fn_sqlvarbasetostr(HashBytes('MD5','1522521276')))
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convert(int,sys.fn_sqlvarbasetostr(HashBytes('MD5','1522521276')))

SIPONIMOD: A NEW VIEW AT THE THERAPY OF SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS
SIPONIMOD: A NEW VIEW AT THE THERAPY OF SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS

To cite this article:

Krasnov VS, Kolontareva YuM. Siponimod: a new view at the therapy of secondary progressive multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(7):124‑129. (In Russ.)
https://doi.org/10.17116/jnevro2021121071124

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
convert(int,sys.fn_sqlvarbasetostr(HashBytes('MD5','1522521276')))
convert(int,sys.fn_sqlvarbasetostr(HashBytes('MD5','1522521276')))
convert(int,sys.fn_sqlvarbasetostr(HashBytes('MD5','1522521276')))
convert(int,sys.fn_sqlvarbasetostr(HashBytes('MD5','1522521276')))
convert(int,sys.fn_sqlvarbasetostr(HashBytes('MD5','1522521276')))
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convert(int,sys.fn_sqlvarbasetostr(HashBytes('MD5','1522521276')))
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Abstract:

Siponimod is a selective modulator of sphingosine-1-phosphate (S1P) receptors of types 1 and 5, registered in the Russian Federation for the treatment of patients with secondary progressive multiple sclerosis (SPMS), regardless of the presence or absence of exacerbations. The effectiveness of the drug in comparison with placebo was demonstrated in patients with SPMS in the international clinical trial EXPAND (phase III). This review devotes actual problems in the treatment of patients with SPMS, discusses the pathophysiology of multiple sclerosis progression, describes the peripheral and central mechanisms of siponimod action and its differences from fingolimod. According to analysis of scientific literature experimental, clinical and neuroimaging data are presented, which could explain the reasons for the successful use of siponimod in patients with SPMS, taking into account the pathophysiological mechanisms of the development of progression and the mechanisms of drug action.

Keywords:

secondary progressive multiple sclerosis
siponimod
neurodegeneration
remyelination

Authors:

Krasnov V.S.

Pavlov First St. Petersburg State Medical University The T-SQL expression convert(int,sys

Kolontareva Yu.M.

Novartis Pharma LLC

Received:

20.04.2021

Accepted:

04.06.2021

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convert(int,sys.fn_sqlvarbasetostr(HashBytes('MD5','1522521276')))
convert(int,sys.fn_sqlvarbasetostr(HashBytes('MD5','1522521276')))

The T-SQL expression convert(int,sys.fn_sqlvarbasetostr(HashBytes('MD5','1522521276'))) returns the integer value . Breakdown of the Execution

: SQL Server takes the beginning of that hex string and attempts to fit it into a 4-byte integer. Because the first 4 bytes ( 0xE4F3F000 ) represent a value larger than the maximum positive signed integer (

: Generates a 128-bit MD5 hash of the string '1522521276'. The resulting binary value is 0xE4F3F000CC6A3F98F7A831A601E6E002 .

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