There is no major 2021 PC game titled exactly "Annihilation From Space." The title likely refers to , an idle simulation game originally released in late 2021. While widely available on mobile, it can be played on PC through official emulation platforms. Annihilation: Space Tycoon (2021)

If the tycoon game is not what you are looking for, you might be thinking of these other "Annihilation" or "Space" themed titles released around the same timeframe: Annihilation - Space Tycoon - Apps on Google Play

The official way to play on PC is via the Google Play Games for PC beta .