Tm,cc,jp May 2026

It tethers vesicles to the plasma membrane, facilitating sound encoding.

Binding Sites: High-resolution structures revealed that multiple Ca 2+raised to the 2 plus power tm,cc,jp

This molecular mechanism allows the ear to convert sound into neural signals at incredibly high speeds. It tethers vesicles to the plasma membrane, facilitating

Lack of functional otoferlin or its C2 domain interaction prevents proper vesicle docking, leading to profound deafness. Summary Table: Otoferlin C2 Interactions Function/Location C2B-C2G Main interface for membrane binding C2D Crucial Ca 2+raised to the 2 plus power binding site; mutations affect sound encoding C2F-C2G Rearrange upon membrane binding to close structure Target Membrane Membrane where vesicles are docked leading to profound deafness.

The protein utilizes several C2 domains (C2A-C2F) to bind Ca 2+raised to the 2 plus power and lipids, as shown in the protein structure below. 2. C2 Domains: Function & Interactions

Based on the 2025 research regarding the protein , which is crucial for hearing and synaptic transmission,

The protein utilizes C2 domains to bridge synaptic vesicles to the plasma membrane (plasma membrane being the "target membrane").